Research Paper Volume 6, Issue 7 pp 524—544
Genome-wide profiling of the microRNA-mRNA regulatory network in skeletal muscle with aging
Figure 7. Association of age-related miRNAs identified in skeletal muscle with human diseases.
(A) The human homologues of 19 of 34 age-related miRNAs (56%) were associated with diseases. Among these, 8 miRNAs (42%) were related to human muscular diseases. Nine of the 34 miRNAs (26%) were not related to disease and 6 miRNAs (18%) had no human homologues. (B) Bar plot for the -log10 of the P-value of the 8 miRNAs enriched for muscular diseases. Becker muscular dystrophy, BMD; dermatomyositis, DM; Duchenne muscular dystrophy, DMD; facioscapulohumeral muscular dystrophy, FSHD; inclusion body myositis, IBM; limb-girdle muscular dystrophies types 2A, LGMD2A; Miyoshi myopathy, MM; nemaline myopathy, NM; polymyositis, PM; rhabdomyosarcoma, RMS.