Research Paper Volume 6, Issue 7 pp 575—586

Figure 4.

Lifelong GH activity predicts senescent cell accumulation in WAT. (A) SA-βgal⁺ cells in 18-month old female Snell dwarf and age-matched non-mutant (NM) littermates. (B) SA-βgal⁺ cells in 18-month old female GHR-/- and age-matched wild-type (WT) littermates. (C) SA-βgal⁺ cells in 10-month old female bGH and age-matched wild-type (WT) controls. (D) SA-βgal⁺ cells in 19-month old female GH-injected (GH-inj.) and age-matched saline-injected (Saline-inj.) controls. E. SA-βgal⁺ cells in female 24 month and 3 month old mice. SA-βgal⁺ data were analyzed by a mixed effects model. All data are expressed as mean ± SEM of 6 mice per group for A-C and 8 mice per group for D-E. ^*P<0.05; ^#P<0.01; ^$P<0.005.