Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice

Michael B. Stout; Tamara Tchkonia; Tamar Pirtskhalava; Allyson K. Palmer; Edward O. List; Darlene E. Berryman; Ellen R. Lubbers; Carlos Escande; Adam Spong; Michal M. Masternak; Ann L. Oberg; Nathan K. LeBrasseur; Richard A. Miller; John J. Kopchick; Andrzej Bartke; James L. Kirkland

doi:doi:http://dx.doi.org/10.18632/aging.100681

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Research Paper Volume 6, Issue 7 pp 575—586

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice

Figure 5.

Speculative model of mechanisms contributing to GH-related WAT dysfunction with aging. Potential links between GH, IGF1, glucose, insulin and cellular senescence are indicated.