Research Paper Volume 6, Issue 8 pp 621—644
D-beta-hydroxybutyrate extends lifespan in C. elegans
Figure 4.
F55E10.6 is required for βHB-mediated lifespan extension, but not for βHB-induced oxygen consumption. (A) Treatment with βHB did not increase the lifespan of N2 worms fed RNAi to F55E10.6. (B) The addition of N-acetyl-L-cysteine (NAC) did not decrease the lifespan of βHB treated worms. (C) The effect of 20 mM βHB and RNAi knockdown of F55E10.6 on oxygen consumption (* p < 0.05 vs. untreated; # p < 0.05 vs. Control). (D) The effect of 20 mM βHB treatment on ATP levels in day 4 N2 worms (p = 0.202). Data are represented as mean +/− SEM.