D-beta-hydroxybutyrate extends lifespan in <i>C. elegans</i>

Clare Edwards; John Canfield; Neil Copes; Muhammad Rehan; David Lipps; Patrick C. Bradshaw

doi:doi:http://dx.doi.org/10.18632/aging.100683

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Research Paper Volume 6, Issue 8 pp 621—644

D-beta-hydroxybutyrate extends lifespan in C. elegans

Figure 9.

βHB extends lifespan in a similar manner as DR and requires AAK-2, SIR-2.1, and CBP-1. (A) βHB does not extend lifespan of AMPK mutant aak-2(TG38) worms, (B) sir-2.1(ok434) worms, or (C) eat-2(ad1116) worms. (D) Additionally, βHB does not extend the lifespan cbp-1 RNAi knockdown N2 worms.