Research Paper Volume 6, Issue 8 pp 675—689

Metabolic clock generates nutrient anticipation rhythms in mTOR signaling

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Figure 5.

NAMO controlled rhythms in TORC1 activity are preserved in the tissues of circadian clock deficient mice. (A and B) Representative western blot (WB) of daily rhythms in phosphorylation of mTORC1 downstream targets in the liver of TR feeding entrained mice with circadian clock disruption. 100% of daily food intake was provided as a single meal at time point 0 (ZT14), tissues were collected at indicated time after feeding (A) Cry2−/− and Cry1,2−/− mice, as indicated; (B) Bmal1−/− mice.