Research Paper Volume 6, Issue 11 pp 975—988
Iron promotes protein insolubility and aging in C. elegans
Figure 2.
Iron supplementation increases susceptibility to toxicity in models of protein aggregation. (A) Kaplan-Meyer curves of wild-type animals exposed to 15 mM FAC from day 1 of adulthood. Iron supplementation significantly decreases lifespan (p<0.0001, Log-rank, Mantel-cox). (B) Iron supplementation increases proteotoxicity in an Aβ expressing transgenic strain after 120 hours of exposure (p<0.0001, Student's t-test). (C, D) Iron supplementation increases the number of polyglutamine inclusions and (E) increases onset of muscle dysfunction in a model of polyglutamine disease after 48 hours of exposure (p<0.0001, p=0.0007 respectively, Student's t-test). Plots are representative of three independent experiments. Error bars, SD.