Research Paper Volume 6, Issue 11 pp 975—988

Iron promotes protein insolubility and aging in C. elegans

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Figure 5.

CaEDTA extends healthspan and lifespan in C. elegans. (A) 2.5 mM CaEDTA exposure from day 1 of adulthood significantly increases motility of 5 day-old animals. (B) Transient exposure to CaEDTA from day 1 of adulthood delays age-related decline of movement in wildtype animals in a dose-dependent manner. (C) Exposure to 2.5 mM CaEDTA for 24 hours increases thermotolerance in wild-type animals. (D) Kaplan-Meyer curve of N2 wildtype worms exposed to 2.5 mM CaEDTA from day 1 of adulthood. Metal chelation significantly increases lifespan (p<0.001, Log-rank, Mantel cox).