Research Paper Volume 6, Issue 11 pp 931—942

Figure 1. Nfkb1^−/− mice have accelerated age-related findings and reduced lifespan.

(A) Representative images of superficial age-related characteristics in Nfkb1^−/− and Nfkb1^+/+ mice at 18 months of age. (B) Kaplan-Meier survival curves of Nfkb1^+/+ (n=11), Nfkb1^+/− (n=13) and Nfkb1^−/− (n=15) littermate mice. p<0.01, Nfkb1^+/+ vs. Nfkb1^−/− and p<0.05, Nfkb1^+/− vs. Nfkb1^−/−, Log rank. (C) Lateral spiral CT images (left) of 12-month old Nfkb1^−/− and Nfkb1^+/+ mice. Quantification of Cobb's Angle (right), in degrees, based on lateral CT image calculated as described in the methods (n=6 for Nfkb1^−/− and n=11 for Nfkb1^+/+). (D) Cortical μCT imaging of femurs from Nfkb1^−/− and Nfkb1^+/+ animals. Representative images of 12-month old femurs are shown. Graphs represent mean cortical thickness (mm), cortical porosity, and cortical bone fraction of 8-week and 12-month old animals (n=3 per group in 8-week old animals and n=4 per group in 12-month old). Data represent mean +/− SEM. *p<0.05.