Research Paper Volume 6, Issue 12 pp 1019—1032
The suppression of ghrelin signaling mitigates age-associated thermogenic impairment
Figure 6. GHS-R directly regulates thermogenic activation in brown adipocytes.
(A) Oxygen consumption of old WT and Ghsr−/− mice after 1.5 mg/Kg subcutaneous injection of NE. N = 10-12. *p<0.05, WT vs. Ghsr−/−. (B) Expression of Ghsr, UCP1 and PPARγ in shGHS-R knockdown HIB1B cells. shScr represents scramble shRNA; shGHS-R represents shRNA specific for GHS-R. N = 9. **p<0.001, shScr vs. shGHS-R.