Research Paper Volume 7, Issue 1 pp 14—25

Functional properties of bone marrow derived multipotent mesenchymal stromal cells are altered in heart failure patients, and could be corrected by adjustment of expansion strategies

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Figure 2. Analysis of in vitro proliferation activity of HD and HF BM-MMSC cells seeded at 3000 cells/cm2 and expanded in normoxia (pO2 =20%).

(A) The population doubling time (PD) at passage 3; Data are presented as mean +/− SEM; n=16 for HF, and n=10 for HD; ** p <0.03; (B) CFU-F frequency in BM-MMSC samples at successive passages; Data are presented as mean +/− SEM; n=5. (C) The correlation analysis between CFU-F frequency and PD in BM-MMSC samples; (D) BM-MMSC CFU with low (left panel) and high (right panel) proliferation rate; (x50).