Research Paper Volume 7, Issue 6 pp 435—449

Figure 4. Survival of NPCs was enhanced in Bmal1‐/‐ mice. Surviving BrdU⁺ cells were analyzed 28 days after the final BrdU administration. (A) Representative photomicrographs of BrdU⁺ cells. (B) Quantification of BrdU+ cells in DG. The number of BrdU+ cells was significantly smaller in Bmal1^‐/‐ as compared to Bmal1^+/+. (C) Linear regression of BrdU⁺ cells one day and 28 days after final BrdU‐injection showed significantly steeper slope in Bmal1^+/+ as compared to Bmal1^‐/‐. (D) Representative photomicrographs showing caspase3⁺ cells. (E) Quantification of caspase3⁺ cells in DG. The number of caspase3⁺ cells was significantly lower in Bmal1^‐/‐ as compared to Bmal1^+/+. Values are given as mean + SEM, *: P <0.05, scale bar = 50 μm.