Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR−/− mice

Edward O. List; Darlene E. Berryman; Yuji Ikeno; Gene B. Hubbard; Kevin Funk; Ross Comisford; Jonathan A. Young; Michael B. Stout; Tamar Tchkonia; Michal M. Masternak; Andrzej Bartke; James L. Kirkland; Richard A. Miller; John J. Kopchick

doi:doi:http://dx.doi.org/10.18632/aging.100766

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Research Paper Volume 7, Issue 7 pp 500—512

Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR−/− mice

Figure 5. Indirect calorimetry, endurance, and grip strength.

(A) Day and night values for VO₂, (B) respiratory exchange ratio, (C) energy expenditure, and (D) activity are shown for MuGHRKO (black bars) and controls (white bars) for males and females. (E) Treadmill endurance and (F) forelimb grip strength values are shown for MuGHRKO and controls. All values are represented as mean + SEM (n=6-8 per group per sex).