Research Paper Volume 7, Issue 7 pp 486—499

Figure 7. The expression of TGF-β1 and CTGF in WT and GMF-TG mice.

(A-B) The expression of transforming growth factor-β1 (TGF-β1) (A) mRNA increased in the kidneys of the GMF-TG mice at 10 weeks, compared with the WT mice. However, no significant differences were shown in the expression of connective tissue growing factor (CTGF) (B) mRNA in the kidney of the GMF-TG mice at 10 weeks, compared with the WT mice. TGF-β1; The data is shown as means ± S.E. (10w WT; n=4, 10w GMF-TG; n=5). CTGF; The data is shown as means ± S.E. (10w WT; n=3, 10w GMF-TG; n=4). *; P < 0.01 vs. 10w WT mice. N.S.; not significant versus 10w WT mice. (C-D) These figures demonstrated a significant increase in TGF-β1 (C) and CTGF (D) mRNA in the kidneys of the GMF-TG mice at 60 weeks, compared with the WT mice at the same age. The data is shown as means ± S.E. (60w WT; n=4, 60w GMF-TG; n=4. *; P < 0.05 vs. 60w WT mice. **; P < 0.001 vs. 60w WT mice.