Research Paper Volume 7, Issue 8 pp 535—552

Figure 4. Sensory receptor mutations increase exercise capacity.

(A) Endurance of both gr64a and or83b mutants is significantly higher than a w¹¹¹⁸ background control (log-rank; p <.0001 for each, n ≥ 100). (B) Exercised w¹¹¹⁸ background control males had significantly less cardiac failure in response to electrical pacing stress than did unexercised cohorts (ANOVA with Tukey post-hoc comparison, p <.0001). Both Gr64a and Or83b flies had significantly less cardiac failure than unexercised w¹¹¹⁸ controls whether exercised or not (ANOVA with Tukey post-hoc comparison, p <.0001). Exercised Or83b flies displayed a higher failure rate than exercised background controls (t-test, p=.0009) while maintaining a failure rate significantly lower than unexercised w¹¹¹⁸ flies (t-test, p <.0001). (C) Unexercised gr64a males have a slower decline in negative geotaxis speed than control males (two-way ANOVA, p <.0001). Nevertheless, gr64a males still display significant improvement in negative geotaxis following training (two-way ANOVA, p <.0001, n ≥ 100). Exercised controls have higher climbing index across ages compared to unexercised controls (two-way ANOVA, p <.0001, n ≥ 100). (D) Unexercised or83b males have a slower decline in negative geotaxis speed than control males (two-way ANOVA, p <.0001, n ≥ 100). Nevertheless, or83b males still display significant improvement in negative geotaxis following training (two-way ANOVA, p <.0001, n ≥ 100). Exercised controls have higher climbing index across ages compared to unexercised controls (two-way ANOVA, p <.0001, n ≥ 100).