Attenuation of p38α MAPK stress response signaling delays the <i>in vivo</i> aging of skeletal muscle myofibers and progenitor cells

John Papaconstantinou; Chen Z. Wang; Min Zhang; San Yang; James Deford; Dmitry V. Bulavin; Naseem H. Ansari

doi:doi:http://dx.doi.org/10.18632/aging.100802

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Research Paper Volume 7, Issue 9 pp 718—733

Attenuation of p38α MAPK stress response signaling delays the in vivo aging of skeletal muscle myofibers and progenitor cells

Figure 4. Cross sections of the gastrocnemius of 20-months old (A) WT and (B) DN-p38α^AF/+ mice.

The cross sections suggest that the age-associated decrease of the diameter of the WT gastrocnemius is delayed in DN-p38α^AF/+ mice. (A) shows a cross section of the gastrocnemius of aged WT (20 mos) mice; (B) shows a cross section of the gastrocnemius of aged DN-p38α^AF/+ (20 mos) mice. (GM), gastrocnemius; (PL), plantaris. (A) anterior; (P) posterior; (M) medial; (L) lateral. (C, D) Maximal cross-sectional area of the gastrocnemius of young (2 mos), middle aged (13.5 mos) and aged (20 mos) mice. (D) A bar graph presentation of the data in (B).