Research Paper Volume 7, Issue 10 pp 776—787

Proteasome function is not impaired in healthy aging of the lung

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Figure 1. Immunoproteasome expression is increased in lung tissue of aged mice.

(A) Overview over the proteasome active site nomenclature. (B) Representative H&E staining of lung from young and aged wildtype C57Bl/6 mice. Images from two individual animals are depicted per group. (C) RTqPCR analysis of proteasome subunit mRNA expression in young and aged wildtype mice. n = 8+SEM. (D) Western blot analysis of proteasome subunit expression in young and aged wildtype mice and quantification of protein expression relative to the β − actin loading control. Bar graphs show mean+SEM.