Research Paper Volume 7, Issue 11 pp 928—936
OTX2 regulates the expression of TAp63 leading to macular and cochlear neuroepithelium development
Figure 4. Schematic representation of OTX2 pathway.
N-Myc has been demonstrated to drive the expression of OTX2, and the latter is able to transactivate TAp63, inducing Hes5 and leading to the differentiation of both cochlear and macular neuroepithelium.