Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program

Mylène Ferrand; Olivier Kirsh; Audrey Griveau; David Vindrieux; Nadine Martin; Pierre-Antoine Defossez; David Bernard

doi:doi:http://dx.doi.org/10.18632/aging.100845

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Research Paper Volume 7, Issue 11 pp 986—999

Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program

Figure 3. Strongly SASP-inducing kinases display strong associations with the NF-κB signaling pathway.

The String database (http://string-db.org/) used to build networks on the basis of known and predicted protein-protein interactions was interrogated with, as entries, the indicated pro-senescence kinases (orange circles). Enrichment in KEGG pathways was used to identify common signaling pathways for the pro-senescence kinases. Proteins defined as belonging to the NF-κB signaling pathway are highlighted by green circles.