Review Volume 7, Issue 12 pp 1050—1065

DNA repair and aging: the impact of the p53 family

class="figure-viewer-img"

Figure 1. Schematic representation of the factors and the pathways that modulate the aging process.

The accumulation of DNA damage plays a pivotal role in triggering the aging process. The progressive failure of the efficiency of the DNA repair mechanisms induces a feedback loop that enforces the aging process.