Research Paper Volume 7, Issue 12 pp 1212—1222

Survival of irradiated recipient mice after transplantation of bone marrow from young, old and “early aging” mice

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Figure 2. Survival proportions of irradiated C57Bl/6 female recipients.

Four week-old female recipients were lethally irradiated with (1050 rads) and transplanted with 2 × 106 BM from 8 week-old (squares, n = 20) or 18 week-old (triangles, n = 17) male C57Bl/6 donors. Recipients of older (18 week-old) BM exhibited reduced longevity compared to recipients of younger (8 week) BM (p<0.001).