Research Paper Volume 7, Issue 12 pp 1212—1222

Survival of irradiated recipient mice after transplantation of bone marrow from young, old and “early aging” mice

class="figure-viewer-img"

Figure 4. Comparison of phenotypes of p53+/m as originally reported in Tyner et al (2002) and those maintained by the Sell group.

(A) Top: Representative 20-month-old skinned p53+/+ female mouse (top) and age- and sex-matched p53+/m mouse (bottom). Pronounced lordokyphosis, loss of body mass, muscle atrophy and loss of adipose tissue is evident in the p53+/m mouse (B and C). Representative of a skinned 20 month-old (B) and 8 month-old male (C) mouse. Both mice possess excessive amounts of adipose tissue and do not exhibit lordokyphosis.