Research Paper Volume 7, Issue 12 pp 1185—1197

Figure 5.

Changes in levels of phosphorylated TGFβ downstream signaling proteins in wounds of AT₁R^−/− and AT₂R^−/− mice. AT₁R^−/− mice have lower expression of Phospho-Smad2 and Phospho-Smad3 in healed skin (day20) as compared to WT. The photomicrographs presented in red fluorescent staining with a blue DAPI counter stain for nuclei at 10x magnification. Quantification of mean fluorescence intensity of phospho-Smads in wild-type and mutant mice is shown. Scale bar 200 μm. *p<0.05.