Research Paper Volume 7, Issue 12 pp 1185—1197

Knockout of Angiotensin AT2 receptors accelerates healing but impairs quality

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Figure 5.

Changes in levels of phosphorylated TGFβ downstream signaling proteins in wounds of AT1R−/− and AT2R−/− mice. AT1R−/− mice have lower expression of Phospho-Smad2 and Phospho-Smad3 in healed skin (day20) as compared to WT. The photomicrographs presented in red fluorescent staining with a blue DAPI counter stain for nuclei at 10x magnification. Quantification of mean fluorescence intensity of phospho-Smads in wild-type and mutant mice is shown. Scale bar 200 μm. *p<0.05.