Expression of amyloid-β in mouse cochlear hair cells causes an early-onset auditory defect in high-frequency sound perception

Yasuhiro Omata; Suganya Tharasegaran; Young-Mi Lim; Yasutoyo Yamasaki; Yasuhito Ishigaki; Takanori Tatsuno; Mitsuo Maruyama; Leo Tsuda

doi:doi:10.18632/aging.100899

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Research Paper Volume 8, Issue 3 pp 427—439

Expression of amyloid-β in mouse cochlear hair cells causes an early-onset auditory defect in high-frequency sound perception

Figure 3. Tg(Math1^E-Aβ42)1Lt and Tg(Math1^E-Aβ42^Arc)1Lt mice show slight hearing defects in high-frequency sound perception. (A-C) ABR thresholds of Tg(Math1^E-Aβ42-ml10g)1Lt (filled circles) and non-Tg (open circles) mice from age 2 to 8 months for the click sound (A), the 32 kHz tone (B), and the 8 kHz tone (C). ABR thresholds were slightly increased from age 3 to 5 months for the 32 kHz tone (B) (arrows). Non-Tg: n = 8 (5 male, 3 female), Tg: n = 10 (6 male, 4 female). (D-F) ABR thresholds of Tg(Math1^E-Aβ42Arc-ml10g)1Lt (filled circles) and non-Tg (open circles) mice from age 2 to 8 months for the click sound (D), the 32 kHz tone (E), and the 8 kHz tone (F). ABR thresholds were slightly increased from age 4 to 5 months for the 32 kHz tone (E) (arrows). Non-Tg: n = 6 (5 male, 1 female), Tg: n = 10 (5 male, 5 female).