Expression of amyloid-β in mouse cochlear hair cells causes an early-onset auditory defect in high-frequency sound perception

Yasuhiro Omata; Suganya Tharasegaran; Young-Mi Lim; Yasutoyo Yamasaki; Yasuhito Ishigaki; Takanori Tatsuno; Mitsuo Maruyama; Leo Tsuda

doi:doi:10.18632/aging.100899

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Research Paper Volume 8, Issue 3 pp 427—439

Expression of amyloid-β in mouse cochlear hair cells causes an early-onset auditory defect in high-frequency sound perception

Figure 5. Hair cell loss in cochleae of Tg(Math1^E-Aβ42^Arc)1Lt/129 mice and control non-Tg siblings at age 8 months. (A) Cochleae of basal region staining with Alexa Fluor 488–phalloidin and DAPI. (B) Middle region of cochleae in non-Tg sibling. (C) Middle region of the cochlea in Tg(Math1^E-Aβ42^Arc)1Lt/129. (D) Basal region of the cochlea in non-Tg sibling. (E) Basal region of the cochlea in Tg(Math1^E-Aβ42^Arc)1Lt/129. OHCs, outer hair cells. The results of the OHCs count at each cochlea turns (% of hair cells loss) are shown in (F) (number of cochleae = 5, in each group). Middle-apex; middle to apex region. Basal; basal region. Data are the mean ± SEM. **P < 0.01.