Research Paper Volume 8, Issue 6 pp 1201—1215
Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice
Figure 6. Increased risk of mortality and premature age-related complications in AdicerKO mice. (A) Insulin tolerance test in young (4-month old) or old (18-month old) male AdicerKO and Lox mice (N=6-7 per condition). Mean ± SEM. * P < 0.05, ** P < 0.01 Lox 18 months vs. AdicerKO 18 months; † P < 0.05 AdicerKO 18 months vs. AdicerKO 4 months. (B,C) Kaplan-Meier curves of (B) male (N=12-16 per genotype) and (C) female (N=10-11 per genotype) Lox and AdicerKO mice. (D) Representative pictures of 24-month old females. Mice were fed ad libitum during these experiments.