Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs)

Marco Fiorillo; Rebecca Lamb; Herbert B. B. Tanowitz; Anna Rita Rita Cappello; Ubaldo E. E. Martinez-Outschoorn; Federica Sotgia; Michael P. P. Lisanti

doi:doi:10.18632/aging.100983

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Research Paper Volume 8, Issue 8 pp 1593—1606

Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs)

Figure 10. Structure of trans-Piceatannol and trans-Resveratrol. (A) Interestingly, these polyphenolic phytochemicals act as inhibitors of the F0F1-ATPase/ATP synthase (Complex V), that is present within the inner membrane of eukaryotic mitochondria. These compounds have been suggested to act as either anti-cancer agents or as compounds that have anti-aging properties. (B) Structural similarities with the bedaquiline molecule are highlighted in orange. Note that the structural backbone of trans-piceatannol and trans-resveratrol is actually embedded within bedaquiline.