Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs)

Marco Fiorillo; Rebecca Lamb; Herbert B. B. Tanowitz; Anna Rita Rita Cappello; Ubaldo E. E. Martinez-Outschoorn; Federica Sotgia; Michael P. P. Lisanti

doi:doi:10.18632/aging.100983

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Research Paper Volume 8, Issue 8 pp 1593—1606

Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs)

Figure 5. Bedaquiline augments oxygen consumption in normal human fibroblasts. The Seahorse XF96 analyzer was employed to determine the mitochondrial function of MCF7 cells treated with 10 μM bedaquiline for 48 hours. (A) The line graph of 3 independent experiments is shown. (B, C, D) Basal respiration, maximal respiration, and ATP levels were all increased by bedaquiline treatment of normal fibroblasts. ** p<0.001.