Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs)

Marco Fiorillo; Rebecca Lamb; Herbert B. B. Tanowitz; Anna Rita Rita Cappello; Ubaldo E. E. Martinez-Outschoorn; Federica Sotgia; Michael P. P. Lisanti

doi:doi:10.18632/aging.100983

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Research Paper Volume 8, Issue 8 pp 1593—1606

Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs)

Figure 8. Bedaquiline has little or no effect on the viability of MCF7 cancer cells and normal human fibroblasts. Bedaquiline (5μM and 10 μM) treatment of MCF7 cells and hTERT-BJ1 normal human fibroblasts was carried out for 5 days. The SRB assay was performed as a measure of cell viability. (A, B) Bedaquiline has little or no inhibitory effects on the viability of MCF7 cells and human fibroblasts. **** p<0.00001, ns not significant.