Research Paper Volume 8, Issue 8 pp 1718—1734
Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates
Figure 7. Metformin delays the conversion of Aβ1-40 from disordered coil to β-sheet structure. Far-UV CD spectra of 50 μM Aβ1-40 at t0 (solid lines), t=0.5 h (dashed lines) and t=2h (dot dashed lines) at 37 °C in the absence (a) and in the presence (b) of 2mM metformin. The signals from the buffer and metformin in buffer have been subtracted from the spectra in (a) and (b), respectively