Research Paper Volume 8, Issue 8 pp 1790—1801
Assessment of the contribution of APOE gene variants to metabolic phenotypes associated with familial longevity at middle age
Figure 1. Graphical presentation of the biological routes through which APOE could affect familial longevity. “Intermediate phenotypes” denotes the metabolic differences between offspring and controls in phenotype (e.g., lower level of serum glucose, lower level of serum 25-hydroxyvitamin D, lower frequency of type 2 diabetes, in LLS offspring compared with controls). In this study, we aim to assess whether this route is plausible.