Research Paper Volume 8, Issue 9 pp 1896—1922

Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARK-AGE Study


Figure 5. DNA methylation profile of TET1 CGI in aging. Graphs represent the CpGs of TET1 CGI analyzed by the epiTYPER assay and show the difference in DNA methylation between the groups of young (34-41) and old (69-74) individuals. Statistical significance was obtained by the Mann-Whitney test (*P < 0.05; **P < 0.01; ***P < 0.001). n(34-41y)=36; n(69-74y)=34. (y)= years.