Research Paper Volume 8, Issue 9 pp 1923—1939
Disruption of mechanical stress in extracellular matrix is related to Stanford type A aortic dissection through down-regulation of Yes-associated protein
Figure 2. (A) Real-time PCR results showing that YAP was significantly down-regulated in the ascending aortic wall of patients with STAAD compared to HTDs (n=19 in HTD group, n=23 in STAAD group, *p=0.0003). (B, C) Western blotting showed that the expression of total YAP proteins was significantly lower in the ascending aortic wall of patients with STAAD compared to HTDs (n=19 in HTD group, n=23 in STAAD group, *p=0.0019). (D) Confocal fluorescence microscopy showing that YAP and α-SMA double stained cells were present at lower numbers and less quantity in patients with STAAD compared to HTDs. (E) Quantified and statistical analyzed of each patient sample’s Western blotting result showed that YAP expression was negatively correlated with the ascending aorta diameter (n=10).