Research Paper Volume 8, Issue 9 pp 1923—1939
Disruption of mechanical stress in extracellular matrix is related to Stanford type A aortic dissection through down-regulation of Yes-associated protein
Figure 5. (A) Western blot showing YAP down-regulation in the PLKO-YAP group compared to the scrambled group. (B, C) Flow cytometry showing increased VSMC apoptosis in the PLKO-YAP group compared to the scrambled group (repeated 3 times for statistical analysis, *p=0.0013). (D) Western blotting showing YAP down-regulation in the experimental group compared to the control group after cyclic stretching. (E, F) Flow cytometry showing increased VSMC apoptosis compared to the control group after cyclic stretching in vitro (the lower right quadrant (Q4) represents the apoptotic VSMCs, and repeated 3 times for statistical analysis, *p=0.0010).