Research Paper Volume 8, Issue 9 pp 2222—2231

Specific premature epigenetic aging of cartilage in osteoarthritis


Figure 1. Comparison of epigenetic age in joint tissues from controls and patients with OA. (A) Accelerated aging in OA cartilage samples (n = 31) in comparison with control cartilage (n = 36) with ΔDmAM = 3.7 years (P = 0.008); and (B) no difference (ΔDmAM = 0.04 years, P = 0.3) in bone samples between OA patients (n = 33) and controls (n = 45). Epigenetic ages are represented as age- and sex-adjusted values with horizontal lines for the mean of each group.