Research Paper Volume 8, Issue 10 pp 2392—2406

Figure 1. (A) Generation of tamoxifen-inducible COX2 transgenic mouse. Diagram of CAG/CAT/hCOX2 construct is shown. (B) Expression of COX2 in various tissues of tamoxifen-inducible COX2 transgenic mouse. COX2 expression was induced in 5-week-old (CAT^flCOX2:Rosa-Cre ERT2) mice by intra-peritoneal injections of tamoxifen. Paraffin-embedded sections of 20-week-old COX2 transgenic mice were stained for COX2 using a human COX2-specific antibody. The tissues shown are heart (a), kidney (b), skeletal muscle (c), pancreas (d), small intestine (e), and skin (f). Scale bar=100 μm (C) General appearance of 20-week-old control (CT) and COX2 transgenic (TG) mice.