Review Volume 8, Issue 10 pp 2290—2307
The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis
Figure 4. Sirt1 regulates oxidative stress. (A) Sirt1 represses p66Shc transcription through deacetylation of the histone H3 lysine 9 promoter. This crosstalk between p66Shc and Sirt1 serves as a mechanism for preventing vascular diseases based on anti-oxidative stress responses. (B) Sirt1 regulates cellular oxidative stress through the induction of anti-oxidative enzymes such as a manganese superoxide dismutase (Mn-SOD), catalase, peroxiredoxins 3 and 5 (Prx3, Prx5), thioredoxin 2 (Trx2), and thioredoxin reductase 2 (TR2) via the deacetylation and activation of Forkhead box O (FOXO) 1, 3, and 4 transcription factors as well as peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) in endothelial cells.