Review Volume 8, Issue 10 pp 2290—2307
The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis
Figure 6C,D. Relationship of autophagy levels to vascular aging and atherosclerosis and the role of Sirt1 in the regulation of autophagy. (C) Sirt1 induces the deacetylation, activation and nuclear translocation of FOXO1. FOXO1 activation stimulates the expression of Rab7, leading to the maturation of autophagosomes and autolysosomes via their fusion with lysosomes. (D) Sirt1 activation deacetylates and activates the FOXO3 transcription factor leading to subsequent Bcl-2/adenovirus E1B-19kDa interacting protein3 (Bnip3) or NIX/Bnip3-Like (Bnip3L)-mediated autophagy.