Expression of Concern
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This article is currently under investigation. We strongly recommend that this article is not cited until the investigation is completed.
Research Paper Volume 8, Issue 10 pp 2509—2524
MicroRNA-346 facilitates cell growth and metastasis, and suppresses cell apoptosis in human non-small cell lung cancer by regulation of XPC/ERK/Snail/E-cadherin pathway
Figure 4. XPC proto-oncogene is a target of miR-346 at specific 3’-UTR sites. (A) The 3’-UTR of XPC harbors one miR-346 cognate site. (B) Relative luciferase activity of reporter plasmids carrying wild-type or mutant XPC 3’-UTR in A549 and SPC-A-1 cells co-transfected with negative control (NC) or miR-346 mimic. (C) Protein expression of XPC in A549 and SPC-A-1 cells after transfected with NC, miR-346, si-XPC and ASO-346. Assays were performed in triplicate. *P < 0.001, Means ± SEM was shown. Statistical analysis was conducted using student t-test.