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Research Paper Volume 8, Issue 10 pp 2590—2602
Article has an altmetric score of 17

Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice

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Figure 5. Old Mtbp heterozygous mouse livers exhibit global elevated metabolic markers. (A-H) Healthy Mtbp+/+ (+/+; n=5; black) and Mtbp+/- (+/-; n=9; gray) mice at 29 months were starved for 5 hours, sacrificed, and livers frozen with Wallenburg clamp. qRT-PCR for (A) glutaminase (Gls, p=0.1147), (B) hexokinase 2 (Hk2, p=0.1401), (C) ornithine decarboxylase (Odc, p=0.0736), (D) carbamoyl-phosphate synthetase 2/aspartate transcarbamylase/dihydroorotase, (Cad, p=0.1393), (E) nucleolin (Ncl, p=0.1412), (F) peroxisome proliferation activated receptor gamma coactivator 1-alpha (Pgc1α, *p=0.0106), (G) Pgc1-beta (Pgc1β, *p=0.0499), and (H) sirtuin-1 (Sirt1, p=0.1529) was performed. Values are relative to β-actin levels. P values calculated using student’s t-tests and error bars are SEM.