Figure 4. Voluntary aerobic exercise restores markers of arterial mitochondrial health in old mice. Aortic protein expression of PGC-1α (A), SIRT-3 (B), Fis1 (C), and Mfn2 (D) in arteries from young control (YC), old control (OC), young voluntary wheel running (YVR) and old voluntary wheel running (OVR) mice. Representative images are presented below each panel with corresponding images of normalizer (beta actin) taken from the same region of the same blot. Data are presented normalized to beta actin and relative to the mean of the YC group as means with error bars representing SEM, n=6-8/group. * p<0.05 vs. YC, # p=0.1 vs. YC.