Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in <i>Saccharomyces cerevisiae</i>

Gregory Tombline; Jonathan I. Millen; Bogdan Polevoda; Matan Rapaport; Bonnie Baxter; Michael Van Meter; Matthew Gilbertson; Joe Madrey; Gary A. Piazza; Lynn Rasmussen; Krister Wennerberg; E. Lucile White; John L. Nitiss; David S. Goldfarb

doi:doi:10.18632/aging.101114

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Research Paper Volume 9, Issue 1 pp 68—97

Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in Saccharomyces cerevisiae

Figure 1. Small molecule effects on DEAD lifespans. Growth rates of DEAD strain (BB579) in the presence of increasing concentrations of nicotinamide (NAM) (A), LS1 (B), ellipticine (ELLIP) (C) and doxorubicin (DOX) (D) under nonpermissive (●) and permissive (○) conditions.