Research Paper Volume 8, Issue 11 pp 3131—3146
Early age decline in DNA repair capacity in the liver: in depth profile of differential gene expression
Figure 2. DEN-induced, age-dependent differential gene expression profiles. Heat maps depicting RNAseq gene expression profiles of mouse liver after DEN treatment. Hierarchical clustering analysis of top 50 differentially expressed transcripts in mouse livers 2 days after DEN treatment compared to control untreated livers in 1-month-old mice (A), 6-month-old mice (B) or genes differentially expressed at day 6 after DEN treatment compared to control in 6-month-old mice (C). Venn diagrams show the number of genes detected as differentially expressed by the DESeq2 package. (D) Comparing day 2 to day 6 in 1-month-old mice. (E) Comparing day 2 in 1-month and 6-month-old mice. (F) Comparing day 2 to day 6 in 6-month-old mice; demonstrating resolution of the response in day 6 in 1-month but not 6-month old mice with relative little overlap in the transcriptional response between the two ages at day 2.