Residual γH2AX foci induced by low dose x-ray radiation in bone marrow mesenchymal stem cells do not cause accelerated senescence in the progeny of irradiated cells

Margarita Pustovalova; Тatiana A. Astrelina; Anna Grekhova; Natalia Vorobyeva; Anastasia Tsvetkova; Taisia Blokhina; Victoria Nikitina; Yulia Suchkova; Daria Usupzhanova; Vitalyi Brunchukov; Irina Kobzeva; Тatiana Karaseva; Ivan V. Ozerov; Aleksandr Samoylov; Andrey Bushmanov; Sergey Leonov; Evgeny Izumchenko; Alex Zhavoronkov; Dmitry Klokov; Andreyan N. Osipov

doi:doi:10.18632/aging.101327

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Research Paper Volume 9, Issue 11 pp 2397—2410

Residual γH2AX foci induced by low dose x-ray radiation in bone marrow mesenchymal stem cells do not cause accelerated senescence in the progeny of irradiated cells

Figure 5. Immunocytochemical analysis of the proliferating (Ki67 positive) cell fraction. (A) Representative microphotographs of the immunofluorescently labeled MSCs with the Ki67 antibody (Ki67+ cells are marked with the arrows). (B) Changes in the percentage of the proliferating cells depending on the passage number in the control and irradiated MSCs. Mean values derived from at least three independent experiments are shown. Error bars show SE.