Research Paper Volume 10, Issue 1 pp 19—33

Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline


Figure 1. Levels of spermidine, spermine, putrescine, and L-Ornithine in whole blood (A,B), brain (C,D) and heart (E,F) after a 28-day oral spermidine supplementation using spermidine-rich plant extract in female (A,C,E) and male (B,D,F) mice (post mortem analysis). The measurements have been conducted on frozen, murine tissue samples using LC/MS-MS analysis of polyamine metabolites. Data is depicted by box plots extending from 25th to 75th percentile and whiskers ranging from the minimum to the maximum value. Individual data points are marked as dots. (n = 5-10 per gender and group).