Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway

Yujie Huang; Xiaohui Zhu; Ka Chen; Hedong Lang; Yong Zhang; Pengfei Hou; Li Ran; Min Zhou; Jiawei Zheng; Long Yi; Mantian Mi; Qianyong Zhang

doi:doi:10.18632/aging.101910

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Research Paper Volume 11, Issue 8 pp 2217—2240

Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway

Figure 1. RSV protects against HFD-induced muscle atrophy in aged rats. (A) Final body weights of the different groups. (B) Weights of GAS, TA and SOL muscles in each group. (C) The relative muscle weights in each group. (D) Representative images of H&E staining of the GAS muscles. Scale bar, 100 μm. (E) Average muscle fiber CSA of the GAS muscles. (F) Grip strength in each group. Data are expressed as the mean ± SD. ^aP < 0.05 vs. the O-group; ^bP < 0.05 vs. the HO-group; ^cP < 0.05 vs. the Y-group; *P < 0.05 for the comparison between the marked groups.