Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway

Yujie Huang; Xiaohui Zhu; Ka Chen; Hedong Lang; Yong Zhang; Pengfei Hou; Li Ran; Min Zhou; Jiawei Zheng; Long Yi; Mantian Mi; Qianyong Zhang

doi:doi:10.18632/aging.101910

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Research Paper Volume 11, Issue 8 pp 2217—2240

Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway

Figure 8. Effects of RSV on mitochondrial function in L6 myotubes. (A) Representative images used for determination of the Δψm in vitro. Scale bar, 20 μm. (B) Ratio of red to green fluorescence. (C) Respiration curve of each group. (D) The bar charts show the quantification of ATP production and maximal respiration. (E) Activities of complexes I, II, and IV. Data are expressed as the mean ± SD. ^aP < 0.05 vs. the control group; ^bP < 0.05 vs. the PA-treated group; ^cP < 0.05 vs. the RSV (25 μM) and PA (0.75 mM) cotreated group with control siRNA transfection.