Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway

Yujie Huang; Xiaohui Zhu; Ka Chen; Hedong Lang; Yong Zhang; Pengfei Hou; Li Ran; Min Zhou; Jiawei Zheng; Long Yi; Mantian Mi; Qianyong Zhang

doi:doi:10.18632/aging.101910

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Research Paper Volume 11, Issue 8 pp 2217—2240

Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway

Figure 9. Effects of RSV on oxidative stress in L6 myotubes. (A) Cellular total ROS levels. (B) mtROS levels. (C and D) Activities of SOD and GPx in vitro. (E) T-AOC in vitro. (F) MDA levels. (G) Carbonyl protein content. Data are expressed as the mean ± SD. ^aP < 0.05 vs. the control group; ^bP < 0.05 vs. the PA-treated group; ^cP < 0.05 vs. the RSV (25 μM) and PA (0.75 mM) cotreated group with control siRNA transfection.