<i>Dlx5</i> and <i>Dlx6</i> expression in GABAergic neurons controls behavior, metabolism, healthy aging and lifespan

Camille de Lombares; Eglantine Heude; Gladys Alfama; Anastasia Fontaine; Rim Hassouna; Cécile Vernochet; Fabrice de Chaumont; Christophe Olivo-Marin; Elodie Ey; Sébastien Parnaudeau; François Tronche; Thomas Bourgeron; Serge Luquet; Giovanni Levi; Nicolas Narboux-Nême

doi:doi:10.18632/aging.102141

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Research Paper Volume 11, Issue 17 pp 6638—6656

Dlx5 and Dlx6 expression in GABAergic neurons controls behavior, metabolism, healthy aging and lifespan

Figure 8. Weight measures during growth and aging. (A-B) The body weight of cohorts of male (A) and female (B) control, Vgat^ΔDlx5-6/+ and Vgat^ΔDlx5-6 mice was measured during the first 16 weeks of growth. At all time points, Vgat^ΔDlx5-6 mice (male and female) displayed a significant weight reduction; Vgat^ΔDlx5-6/+ males had also a significantly lower weight, while, during growth, until 11 weeks of age, the weight of female Vgat^ΔDlx5-6/+ was not significantly different than controls (B). (C) The body weight of a cohorts of male control, Vgat^ΔDlx5-6/+ and Vgat^ΔDlx5-6 mice (n ≥ 8 per group) was measured during the first 20 months of aging. At all time points analyzed Vgat^ΔDlx5-6/+ and Vgat^ΔDlx5-6 male mice presented a highly significant weight reduction.