Oxidative stress-induced cellular senescence desensitizes cell growth and migration of vascular smooth muscle cells through down-regulation of platelet-derived growth factor receptor-beta

Chun-Hsu Pan; Chang-Jui Chen; Chun-Ming Shih; Ming-Fu Wang; Jie-Yu Wang; Chieh-Hsi Wu

doi:doi:10.18632/aging.102270

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Research Paper Volume 11, Issue 19 pp 8085—8102

Oxidative stress-induced cellular senescence desensitizes cell growth and migration of vascular smooth muscle cells through down-regulation of platelet-derived growth factor receptor-beta

Figure 2. Influence of cellular senescence on the proliferative and migratory capacities of A10 cells. Senescence was produced in cells by a 72-hr incubation with 300 μM CoCl₂. After that, platelet-derived growth factor (PDGF)-BB-stimulated cell proliferation and migration were respectively analyzed by an MTT assay (A) and wound-healing analysis (B). * p < 0.05 compared to the normal cell group.